Consulting on Ophthalmic Research
At VO-CRO, we are uniquely positioned because of our alignment with an academic medical center. We have access to facilities with high-end equipment that allow us to complete the highest-quality research and analysis in pre-clinical ophthalmic diseases. Our team of experts have decades of experience which enables us to accommodate clients with more than just data. Our senior staff can consult on:
Assessment of the current ocular drug development landscape
Current experimental standards for ocular drug development
Target identification
Target validation strategies
Experimental model selection
Experimental design
IND portfolio development
Mechanism of action determination
PK strategies
Formulation strategies
Toxicity determination strategies
Other topics
Discover more with VO-CRO
Schedule A ConsultationOphthalmic Research Models
Our organization is dedicated to offering advanced ocular models such as:
In Vitro
We retrieve high-quality data from isolating and culturing primary cells from mouse, rat, and human. We have years of experience developing methods that allow us to transfect each cell type. Types include:
- Choroidal Endothelial Cells
- Retinal Microvascular Endothelial Cells
- Pericytes
- Müller Glia
- Retinal Pigmented Epithelium
- Astrocytes
- Microglia
- Neurons
Ex Vivo
We isolate ocular tissues, including retina and choroid, from a variety of animal species and models for use in assays studying tissue properties and behaviors. Readouts include:
- Angiogenesis
- Inflammatory mediator expression and creation
- Neuroprotection and neuronal apoptosis
- Apoptosis
In Vivo
Our animal research is supported by a team of 75 full-time employees from the Division of Animal Care (DAC). The DAC provides veterinary care and husbandry services for over twenty species of vertebrate animals. Models include:
- Oxygen-Induced Retinopathy
- Diabetic Retinopathy
- Laser-Induced Choroidal Neovascularization
- Retinal Degeneration
- Ischemia-Reperfusion Injury
- Retinal Vein Occlusion
Get more information about our experiments and deliverables.
Fees and GuidelinesOcular Model Training
VO-CRO staff members are poised to train your personnel in cell- and animal-based study techniques to facilitate your discovery and drug development efforts. We have extensive expertise with cell-based models of growth factor and cytokine induction by disease-relevant stimuli and of induced cell behaviors relevant to ocular disease. We also have long-standing experience with animal models of ocular angiogenesis, vascular regression, vascular inflammation, and neurodegeneration.